Regulatory Mechanisms of Autophagy-Targeted Antimicrobial Therapeutics Against Mycobacterial Infection
نویسندگان
چکیده
منابع مشابه
Advances in Autophagy Regulatory Mechanisms
Autophagy plays a critical role in cell metabolism by degrading and recycling internal components when challenged with limited nutrients. This fundamental and conserved mechanism is based on a membrane trafficking pathway in which nascent autophagosomes engulf cytoplasmic cargo to form vesicles that transport their content to the lysosome for degradation. Based on this simple scheme, autophagy ...
متن کاملMicroRNA-125a Inhibits Autophagy Activation and Antimicrobial Responses during Mycobacterial Infection.
MicroRNAs (miRNAs) are small noncoding nucleotides that play critical roles in the regulation of diverse biological functions, including the response of host immune cells. Autophagy plays a key role in activating the antimicrobial host defense against Mycobacterium tuberculosis. Although the pathways associated with autophagy must be tightly regulated at a posttranscriptional level, the contrib...
متن کاملMolecular mechanisms of cardiovascular toxicity of targeted cancer therapeutics.
In 2002, Hoshijima and Chien drew largely theoretical parallels between the dysregulation of the signaling pathways driving cancer and those driving cardiac hypertrophy (Hoshijima M, Chien KR. J Clin Invest. 2002;109:849-855). On the surface, this statement appeared to stretch the limits of reason, given the fact that cancer cells are known for their proliferative capacity, and adult cardiomyoc...
متن کاملMechanisms of resistance to ErbB-targeted cancer therapeutics.
The ErbB receptors, such as EGFR, have been intensely pursued as targets for cancer therapeutics. However, a large percentage of patients who are initially responsive to ErbB-targeted therapies experience tumor recurrence and become refractory to therapy. In this issue of the JCI, Guix et al. demonstrate that downregulation of IGF-binding protein 3 (IGFBP-3) and -4, the negative regulators of I...
متن کاملTargeted Therapeutics
Deciphering the molecular underpinnings of a disease is often only the first step toward developing an effective treatment. The path from target identification to a successful therapeutic can be filled with numerous hurdles that call for creative strategies. This Select highlights recent advances in using gene therapy and engineered cells to treat cancers and chronic heart disease. Their succes...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Cellular and Infection Microbiology
سال: 2021
ISSN: 2235-2988
DOI: 10.3389/fcimb.2021.633360